Transaction · 0001636282-26-000117

Burrows Scott L

Burrows Scott L, CFO, reported a transaction classified as exercise at Spyre Therapeutics, Inc. involving 7500.000000 shares for an estimated $108750.00. Reported holdings after the transaction were 87262.000000 shares. The stored filing text includes a detected 10b5-1 reference.

exerciseSEC transaction code MCFO
SYRESpyre Therapeutics, Inc.
Filing timeOct 03
Trade dateOct 01, 2026
Filing · SECView on SEC
InsiderProfile
% of reported position tradedUnavailableCalculated only for code-P purchases and code-S sales.

Row-level estimate for this security and ownership context, not the insider’s complete portfolio. Joint ownership, other transactions in the filing, amendments and footnotes can affect interpretation.

Price performance since filing

Close on the filing date, the pre-filing context, and the forward return at standard windows
Price at filing
$93.19
Pre-filing
1mo ago -5.0%1w ago -6.5%1d ago -4.5%
Returns since
7d30d90d180d1y

SYRE price since this filing

30 days of pre-filing context and vertical markers at the filing date plus 7d / 30d / 90d / 180d / 1y afterwards
SYRE since 2026-10-03Filed today · pre-filing context shaded
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Filing datePost-filing windows (7d, 30d, 90d, 180d, 1y)30 days of pre-filing context

Transaction facts

Stored Form 4 columns with their raw values

Non-derivative
Type
exercise
Code M
Identifier
0001636282-26-000117
Common Stock
Transaction date
Oct 01, 2026
Filed Oct 03, 2026, 01:29 AM · 2d delay
Shares
7.50k sh
$14.50 per share
Estimated value
$108k
Computed from shares × price
Holdings after
87.2k sh
Direct

Filing signal explanations

Badges describe filing facts only — not predictions.

Cluster 14dRepeat 30dPattern $100kLarge $1.00M
Direct Ownership 10b5-1 Detected
0score
Filing-only score

0

Compact filing score computed from stored Form 4 facts. Version v1.

Neutral filing signal

This filing is broadly neutral on the filing-only scale. The Form 4 facts do not strongly tilt positive or negative.

Reported relationships & other filings

Form 4 relationship flags and nearby filing context

Reported roles

Chief Financial Officer

Officer YesDirector No10% NoOther No
Footnotes & amended
  1. F1

    The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $89.00 to $90.62, inclusive. The Reporting Person undertakes to provide to

  2. (2 footnotes)

    the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate p…

  3. (2 footnotes)

    within the range.

  4. F2

    This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

  5. F3

    The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $88.63 to $89.53, inclusive. The Reporting Person undertakes to provide to

  6. F4

    The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $89.96 to $90.95, inclusive. The Reporting Person undertakes to provide to

  7. (4 footnotes)

    the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

  8. F5

    The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $91.41 to $92.26, inclusive. The Reporting Person undertakes to provide to

  9. F6

    The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $92.54 to $93.53, inclusive. The Reporting Person undertakes to provide to

  10. F7

    The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $93.54 to $93.59, inclusive. The Reporting Person undertakes to provide to

  11. F8

    Includes 33,738 RSUs. Each RSU represents a contingent right to receive, upon vesting, one share of the Issuer's common stock. The RSUs vest on September 1, 2027, subject to the Reporting Person's con…

  12. F9

    This option represents a right to purchase 404,857 shares of the Issuer's common stock (which have been adjusted to reflect the Issuer's 1-for-25 reverse stock split on September 8, 2023), one quarter…

  13. of which vested and became exercisable on September 1, 2024, with the remaining three quarters vesting in monthly installments over the following three years, subject to the Reporting Person's

  14. continued employment with the Issuer.

Original filing · 0001636282-26-000117
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